Striatal amyloid is associated with tauopathy and memory decline in familial Alzheimer’s disease

Striatal amyloid is associated with tauopathy and memory decline in familial Alzheimer’s disease

Abstract Background Autosomal dominant Alzheimer’s disease (ADAD) is distinguished from late-onset AD by early striatal amyloid-β deposition. To determine whether striatal Pittsburgh compound B (PiB)-PET measurements of amyloid-β can help predict disease severity in ADAD, we compared relationships o...

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Bibliographic Details
Main Authors: Bernard J. Hanseeuw, Francisco Lopera, Reisa A. Sperling, Daniel J. Norton, Edmarie Guzman-Velez, Ana Baena, Enmanuelle Pardilla-Delgado, Aaron P. Schultz, Jennifer Gatchel, David Jin, Kewei Chen, Eric M. Reiman, Keith A. Johnson, Yakeel T. Quiroz
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Alzheimer’s Research & Therapy
Subjects:
Early-onset autosomal dominant Alzheimer’s disease
Striatum
Tau PET
Amyloid PET
Memory
Online Access:http://link.springer.com/article/10.1186/s13195-019-0468-1

Internet

http://link.springer.com/article/10.1186/s13195-019-0468-1

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