Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory

Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory

SNX6 is a ubiquitously expressed PX-BAR protein that plays important roles in retromer-mediated retrograde vesicular transport from endosomes. Here we report that CNS-specific Snx6 knockout mice exhibit deficits in spatial learning and memory, accompanied with loss of spines from distal dendrites of...

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Bibliographic Details
Main Authors: Yang Niu, Zhonghua Dai, Wenxue Liu, Cheng Zhang, Yanrui Yang, Zhenzhen Guo, Xiaoyu Li, Chenchang Xu, Xiahe Huang, Yingchun Wang, Yun S Shi, Jia-Jia Liu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
SNX6
Homer1b/c
dendritic distribution
AMPAR
dendritic spine
spatial memory
Online Access:https://elifesciences.org/articles/20991

Internet

https://elifesciences.org/articles/20991

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