Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer
In eukaryotes the SLC35 family of solute carriers mediate the selective uptake of nucleotide sugars from the cytoplasm into the Endoplasmic Reticulum or Golgi. Here authors report the crystal structure of the yeast GDP-mannose transporter, Vrg4, bound to guanine monophosphate (GMP) revealing the mol...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12673-w |