Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer

Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer

In eukaryotes the SLC35 family of solute carriers mediate the selective uptake of nucleotide sugars from the cytoplasm into the Endoplasmic Reticulum or Golgi. Here authors report the crystal structure of the yeast GDP-mannose transporter, Vrg4, bound to guanine monophosphate (GMP) revealing the mol...

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Main Authors: Joanne L. Parker, Robin A. Corey, Phillip J. Stansfeld, Simon Newstead
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12673-w
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spelling doaj-4b7a5b5b1b9d40119097e2135d10ed602021-05-11T12:04:18ZengNature Publishing GroupNature Communications2041-17232019-10-0110111010.1038/s41467-019-12673-wStructural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayerJoanne L. Parker0Robin A. Corey1Phillip J. Stansfeld2Simon Newstead3Department of Biochemistry, University of OxfordDepartment of Biochemistry, University of OxfordSchool of Life Sciences & Department of Chemistry, The University of WarwickDepartment of Biochemistry, University of OxfordIn eukaryotes the SLC35 family of solute carriers mediate the selective uptake of nucleotide sugars from the cytoplasm into the Endoplasmic Reticulum or Golgi. Here authors report the crystal structure of the yeast GDP-mannose transporter, Vrg4, bound to guanine monophosphate (GMP) revealing the molecular basis for GMP recognition and transport.https://doi.org/10.1038/s41467-019-12673-w
collection DOAJ
language English
format Article
sources DOAJ
author Joanne L. Parker
Robin A. Corey
Phillip J. Stansfeld
Simon Newstead
spellingShingle Joanne L. Parker
Robin A. Corey
Phillip J. Stansfeld
Simon Newstead
Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer
Nature Communications
author_facet Joanne L. Parker
Robin A. Corey
Phillip J. Stansfeld
Simon Newstead
author_sort Joanne L. Parker
title Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer
title_short Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer
title_full Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer
title_fullStr Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer
title_full_unstemmed Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer
title_sort structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-10-01
description In eukaryotes the SLC35 family of solute carriers mediate the selective uptake of nucleotide sugars from the cytoplasm into the Endoplasmic Reticulum or Golgi. Here authors report the crystal structure of the yeast GDP-mannose transporter, Vrg4, bound to guanine monophosphate (GMP) revealing the molecular basis for GMP recognition and transport.
url https://doi.org/10.1038/s41467-019-12673-w
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AT robinacorey structuralbasisforsubstratespecificityandregulationofnucleotidesugartransportersinthelipidbilayer
AT phillipjstansfeld structuralbasisforsubstratespecificityandregulationofnucleotidesugartransportersinthelipidbilayer
AT simonnewstead structuralbasisforsubstratespecificityandregulationofnucleotidesugartransportersinthelipidbilayer
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