Marine Actinomycetes-Derived Secondary Metabolites Overcome TRAIL-Resistance via the Intrinsic Pathway through Downregulation of Survivin and XIAP

Marine Actinomycetes-Derived Secondary Metabolites Overcome TRAIL-Resistance via the Intrinsic Pathway through Downregulation of Survivin and XIAP

Resistance of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis represents the major hurdle to the clinical use of TRAIL or its derivatives. The discovery and development of lead compounds able to sensitize tumor cells to TRAIL-induced cell death is th...

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Bibliographic Details
Main Authors: Mohammed I.Y. Elmallah, Sheron Cogo, Andrei A. Constantinescu, Selene Elifio-Esposito, Mohammed S. Abdelfattah, Olivier Micheau
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
TRAIL
marine actinomycetes
apoptosis
therapy
Online Access:https://www.mdpi.com/2073-4409/9/8/1760

Internet

https://www.mdpi.com/2073-4409/9/8/1760

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