Targeting Cytokine Release Through the Differential Modulation of Nrf2 and NF-κB Pathways by Electrophilic/Non-Electrophilic Compounds

Targeting Cytokine Release Through the Differential Modulation of Nrf2 and NF-κB Pathways by Electrophilic/Non-Electrophilic Compounds

The transcription factor Nrf2 coordinates a multifaceted response to various forms of stress and to inflammatory processes, maintaining a homeostatic intracellular environment. Nrf2 anti-inflammatory activity has been related to the crosstalk with the transcription factor NF-κB, a pivotal mediator o...

Full description

Bibliographic Details
Main Authors: Francesca Fagiani, Michele Catanzaro, Erica Buoso, Filippo Basagni, Daniele Di Marino, Stefano Raniolo, Marialaura Amadio, Eric H. Frost, Emanuela Corsini, Marco Racchi, Tamas Fulop, Stefano Govoni, Michela Rosini, Cristina Lanni
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pharmacology
Subjects:
Nrf2
NF-κB
curcumin
antioxidant
inflammation
cytokine release
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01256/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01256/full

Similar Items