RNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery in Caenorhabditis elegans

RNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery in Caenorhabditis elegans

Cullin-RING E3-Ligases (CRLs), the largest family of E3 ubiquitin-Ligases, regulate diverse cellular processes by promoting ubiquitination of target proteins. The evolutionarily conserved Leucine Rich Repeat protein 1 (LRR-1) is a substrate-recognition subunit of a CRL2LRR-1 E3-ligase. Here we provi...

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Bibliographic Details
Main Authors: Batool Ossareh-Nazari, Anthi Katsiarimpa, Jorge Merlet, Lionel Pintard
Format: Article
Language:English
Published: Oxford University Press 2016-10-01
Series:G3: Genes, Genomes, Genetics
Subjects:
Cullin-RING E3-Ligases
DNA replication
C. elegans
Mutant Screen Report
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.116.033043

Internet

http://g3journal.org/lookup/doi/10.1534/g3.116.033043

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