Carbamazepine treatment recovered low N-acetylaspartate+N-acetylaspartylglutamate (tNAA) levels in the megencephaly mouse BALB/cByJ-Kv1.1mceph/mceph

Carbamazepine treatment recovered low N-acetylaspartate+N-acetylaspartylglutamate (tNAA) levels in the megencephaly mouse BALB/cByJ-Kv1.1mceph/mceph

Megencephaly mice (BALB/cByJ-Kv1.1mceph/mceph) display excessive brain growth and seizures related to a mutation within the potassium channel gene Kv1.1 producing a malfunctioning protein. 1H Magnetic resonance spectroscopy (MRS) provides means to study brain transmitters and metabolites in vivo. We...

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Bibliographic Details
Main Authors: Eric Westman, Christian Spenger, Lars-Olof Wahlund, Catharina Lavebratt
Format: Article
Language:English
Published: Elsevier 2007-04-01
Series:Neurobiology of Disease
Subjects:
MRS
LCModel
PLS-DA
Epilepsy
mceph/mceph
Carbamazepine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106003263

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http://www.sciencedirect.com/science/article/pii/S0969996106003263

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