Ulinastatin Inhibits Osteoclastogenesis and Suppresses Ovariectomy-Induced Bone Loss by Downregulating uPAR

Ulinastatin Inhibits Osteoclastogenesis and Suppresses Ovariectomy-Induced Bone Loss by Downregulating uPAR

Recent studies indicate that uPAR acts a crucial part in cell migration and the modulation of bone homeostasis. As a natural serine protease inhibitor, ulinastatin owns the capacity to reduce proinflammatory factors, downregulate the activation of NF-κB and mitogen-activated protein kinases (MAPKs)...

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Bibliographic Details
Main Authors: Jun-ming Huang, Ran-yue Ren, Yuan Bao, Jia-chao Guo, Wei Xiang, Xing-zhi Jing, Jia Shi, Guo-xiang Zhang, Long Li, Yong Tian, Hao Kang, Feng-jin Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Pharmacology
Subjects:
ulinastatin
uPAR
osteoclast
MAPKs
NF-κB
RANKL
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01016/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01016/full

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