Genetic Modification of CD8+ T Cells to Express EGFR: Potential Application for Adoptive T Cell Therapies

Genetic Modification of CD8+ T Cells to Express EGFR: Potential Application for Adoptive T Cell Therapies

Adoptive immunotherapy with ex vivo-expanded tumor-infiltrating lymphocytes (TILs) has achieved objective clinical responses in a significant number of patients with cancer. The failure of many patients to develop long-term tumor control may be, in part, due to exhaustion of transferred T cells in t...

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Bibliographic Details
Main Authors: Teresa Lozano, Silvia Chocarro, Celia Martin, Aritz Lasarte-Cia, Cynthia del Valle, Marta Gorraiz, Patricia Sarrión, Marina Ruiz de Galarreta, Amaia Lujambio, Sandra Hervás-Stubbs, Pablo Sarobe, Noelia Casares, Juan J. Lasarte
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
epidermal growth factor receptor EGFR
EGFR ligands
adoptive cell therapy
genetic modification
CD8+ T cells
tumor microenvironment
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02990/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02990/full

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