Wfs1-deficient mice display altered function of serotonergic system and increased behavioural response to antidepressants

Wfs1-deficient mice display altered function of serotonergic system and increased behavioural response to antidepressants

It has been shown that mutations in the WFS1 gene make humans more susceptible to mood disorders. Besides that, mood disorders are associated with alterations in the activity of serotonergic and noradrenergic systems. Therefore, in this study, the effects of imipramine, an inhibitor of serotonin (5-...

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Bibliographic Details
Main Authors: Tanel eVisnapuu, Sirli eRaud, Maarja eLoomets, Riin eReimets, Silva eSütt, Hendrik eLuuk, Mario ePlaas, Sulev eKõks, Vallo eVolke, Aet eAlttoa, Jaanus eHarro, Eero eVasar
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-07-01
Series:Frontiers in Neuroscience
Subjects:
Imipramine
Paroxetine
forced swimming test
behavioural despair
tail suspension test
serotonin reuptake transporter
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00132/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00132/full

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