Both T cell priming in lymph node and CXCR3-dependent migration are the key events for predicting the response of atezolizumab

Both T cell priming in lymph node and CXCR3-dependent migration are the key events for predicting the response of atezolizumab

Abstract Anti-PD-L1 antibodies benefit many cancer patients, even those with “non-inflamed tumor”. Determining which patients will benefit remains an important clinical goal. In a non-inflamed tumor mouse model, we found that PD-L1 was highly expressed on antigen-presenting cells (APCs) especially o...

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Bibliographic Details
Main Authors: Toshiki Iwai, Masamichi Sugimoto, Namrata S. Patil, Daniel Bower, Miho Suzuki, Chie Kato, Keigo Yorozu, Mitsue Kurasawa, David S. Shames, Osamu Kondoh
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-93113-y

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https://doi.org/10.1038/s41598-021-93113-y

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