An Integrated Approach to Identify New Anti-Filarial Leads to Treat River Blindness, a Neglected Tropical Disease

An Integrated Approach to Identify New Anti-Filarial Leads to Treat River Blindness, a Neglected Tropical Disease

Filarial worms cause multiple debilitating diseases in millions of people worldwide, including river blindness. Currently available drugs reduce transmission by killing larvae (microfilariae), but there are no effective cures targeting the adult parasites (macrofilaricides) which survive and reprodu...

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Bibliographic Details
Main Authors: Rahul Tyagi, Christina A. Bulman, Fidelis Cho-Ngwa, Chelsea Fischer, Chris Marcellino, Michelle R. Arkin, James H. McKerrow, Case W. McNamara, Matthew Mahoney, Nancy Tricoche, Shabnam Jawahar, James W. Janetka, Sara Lustigman, Judy Sakanari, Makedonka Mitreva
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Pathogens
Subjects:
parasitic nematodes
filarial nematodes
whole worm assay
in vitro
target class repurposing
anthelmintics
Online Access:https://www.mdpi.com/2076-0817/10/1/71

Internet

https://www.mdpi.com/2076-0817/10/1/71

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