Overexpression of Exportin-5 Overrides the Inhibitory Effect of miRNAs Regulation Control and Stabilize Proteins via Posttranslation Modifications in Prostate Cancer

Overexpression of Exportin-5 Overrides the Inhibitory Effect of miRNAs Regulation Control and Stabilize Proteins via Posttranslation Modifications in Prostate Cancer

Although XPO5 has been characterized to have tumor-suppressor features in the miRNA biogenesis pathway, the impact of altered expression of XPO5 in cancers is unexplored. Here we report a novel “oncogenic” role of XPO5 in advanced prostate cancer. Using prostate cancer models, we found that excess l...

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Bibliographic Details
Main Authors: Naseruddin Höti, Shuang Yang, Paul Aiyetan, Binod Kumar, Yingwei Hu, David Clark, Arife Unal Eroglu, Punit Shah, Tamara Johnson, Wasim H. Chowdery, Hui Zhang, Ronald Rodriguez
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558617302427

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http://www.sciencedirect.com/science/article/pii/S1476558617302427

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