Early Everolimus Initiation Fails to Counteract the Cytotoxic Response Mediated by CD8+ T and NK Cells in Heart Transplant Patients

Early Everolimus Initiation Fails to Counteract the Cytotoxic Response Mediated by CD8+ T and NK Cells in Heart Transplant Patients

The positive long-term effects of conversion to everolimus (EVL) after heart transplantation (HT) have been evaluated in several studies. However, the timing of EVL initiation, the best way to combine it with other immunosuppressive treatments, and the impact of these combinations on the immune resp...

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Bibliographic Details
Main Authors: Beatriz Díaz-Molina, Paula Diaz-Bulnes, Reyes Carvajal Palao, Maria José Bernardo, Ramón M. Rodriguez, Viviana Corte-Iglesias, Cesar Moris de la Tassa, Jose Luis Lambert, Beatriz Suarez-Alvarez
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
everolimus
heart transplantation
cytotoxicity
DNA methylation
CD8+ T cells
NK cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02181/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02181/full

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