Establishment of drug-resistant HBV small-animal models by hydrodynamic injection
In antiviral therapy of hepatitis B virus (HBV) infection, drug resistance remains a huge obstacle to the long-term effectiveness of nucleoside/tide analogs (NAs). Primary resistance mutation (rtM204V) contributes to lamivudine (LAM)-resistance, and compensatory mutations (rtL180M and rtV173L) resto...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2014-08-01
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Series: | Acta Pharmaceutica Sinica B |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383514000616 |