Somatotroph Tumors and the Epigenetic Status of the <i>GNAS</i> Locus

Somatotroph Tumors and the Epigenetic Status of the <i>GNAS</i> Locus

Forty percent of somatotroph tumors harbor recurrent activating <i>GNAS</i> mutations, historically called the <i>gsp</i> oncogene. In <i>gsp</i>-negative somatotroph tumors, <i>GNAS</i> expression itself is highly variable; those with <i>GNAS<...

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Bibliographic Details
Main Authors: Pauline Romanet, Justine Galluso, Peter Kamenicky, Mirella Hage, Marily Theodoropoulou, Catherine Roche, Thomas Graillon, Heather C. Etchevers, Daniel De Murat, Grégory Mougel, Dominique Figarella-Branger, Henry Dufour, Thomas Cuny, Guillaume Assié, Anne Barlier
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
pituitary
<i>GNAS</i>
gsp oncogene
somatotroph
tumorigenesis
epigenetic
Online Access:https://www.mdpi.com/1422-0067/22/14/7570

Internet

https://www.mdpi.com/1422-0067/22/14/7570

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