PPARalpha siRNA-treated expression profiles uncover the causal sufficiency network for compound-induced liver hypertrophy.

PPARalpha siRNA-treated expression profiles uncover the causal sufficiency network for compound-induced liver hypertrophy.

Uncovering pathways underlying drug-induced toxicity is a fundamental objective in the field of toxicogenomics. Developing mechanism-based toxicity biomarkers requires the identification of such novel pathways and the order of their sufficiency in causing a phenotypic response. Genome-wide RNA inter...

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Main Authors: Xudong Dai, Angus T De Souza, Hongyue Dai, David L Lewis, Chang-kyu Lee, Andy G Spencer, Hans Herweijer, Jim E Hagstrom, Peter S Linsley, Douglas E Bassett, Roger G Ulrich, Yudong D He
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-03-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC1808491?pdf=render

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http://europepmc.org/articles/PMC1808491?pdf=render

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