Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI

Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI

Summary: Tissue-specific mechanisms prompting obesity-related development complications in humans remain unclear. We apply multiomics analyses of subcutaneous adipose tissue and skeletal muscle to examine the effects of acquired obesity among 49 BMI-discordant monozygotic twin pairs. Overall, adipos...

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Bibliographic Details
Main Authors: Birgitta W. van der Kolk, Sina Saari, Alen Lovric, Muhammad Arif, Marcus Alvarez, Arthur Ko, Zong Miao, Navid Sahebekhtiari, Maheswary Muniandy, Sini Heinonen, Ali Oghabian, Riikka Jokinen, Sakari Jukarainen, Antti Hakkarainen, Jesper Lundbom, Juho Kuula, Per-Henrik Groop, Taru Tukiainen, Nina Lundbom, Aila Rissanen, Jaakko Kaprio, Evan G. Williams, Nicola Zamboni, Adil Mardinoglu, Päivi Pajukanta, Kirsi H. Pietiläinen
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports Medicine
Subjects:
obesity
twins
adipose tissue
skeletal muscle
multiomics
transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379121000422

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http://www.sciencedirect.com/science/article/pii/S2666379121000422

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