PDE7B is a novel, prognostically significant mediator of glioblastoma growth whose expression is regulated by endothelial cells.

PDE7B is a novel, prognostically significant mediator of glioblastoma growth whose expression is regulated by endothelial cells.

Cell-cell interactions between tumor cells and constituents of their microenvironment are critical determinants of tumor tissue biology and therapeutic responses. Interactions between glioblastoma (GBM) cells and endothelial cells (ECs) establish a purported cancer stem cell niche. We hypothesized t...

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Bibliographic Details
Main Authors: Michael D Brooks, Erin Jackson, Nicole M Warrington, Jingqin Luo, Jason T Forys, Sara Taylor, Diane D Mao, Jeffrey R Leonard, Albert H Kim, David Piwnica-Worms, Robi D Mitra, Joshua B Rubin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4159344?pdf=render

Internet

http://europepmc.org/articles/PMC4159344?pdf=render

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