Wnt-Dependent Activation of ERK Mediates Repression of Chondrocyte Fate during Calvarial Development

Wnt-Dependent Activation of ERK Mediates Repression of Chondrocyte Fate during Calvarial Development

Wnt signaling regulates cell fate decisions in diverse contexts during development, and loss of Wnt signaling in the cranial mesenchyme results in a robust and binary cell fate switch from cranial bone to ectopic cartilage. The Extracellular signal-regulated protein kinase 1 and 2 (ERK1/2) and Wnt s...

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Bibliographic Details
Main Authors: Beatriz A Ibarra, Cody Machen, Radhika P. Atit
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Journal of Developmental Biology
Subjects:
craniofacial development
cell signaling
Wnt signaling
ERK signaling
cell fate
Online Access:https://www.mdpi.com/2221-3759/9/3/23

Internet

https://www.mdpi.com/2221-3759/9/3/23

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