PD-L1-Mediated Immunosuppression in Glioblastoma Is Associated With the Infiltration and M2-Polarization of Tumor-Associated Macrophages

PD-L1-Mediated Immunosuppression in Glioblastoma Is Associated With the Infiltration and M2-Polarization of Tumor-Associated Macrophages

There has been no significant improvements for immune checkpoint inhibitors since its first use. Tumour-associated macrophages (TAMs) are critical mediators in the PD-1/PD-L1 axis, contributing to the immunosuppressive tumour microenvironment. This study aims to investigate the potential role of PD-...

Full description

Bibliographic Details
Main Authors: Zhiyuan Zhu, Hongbo Zhang, Baodong Chen, Xing Liu, Shizhong Zhang, Zhitao Zong, Mengqi Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
immune checkpoint inhibitor
PD-1/PD-L1 axis
glioblastoma tumor microenvironment
immunosuppression
tumor-associated macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.588552/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.588552/full

Similar Items