Mucosal associated invariant T cells from human breast ducts mediate a Th17-skewed response to bacterially exposed breast carcinoma cells

Mucosal associated invariant T cells from human breast ducts mediate a Th17-skewed response to bacterially exposed breast carcinoma cells

Abstract Background Antimicrobial T cells play key roles in the disease progression of cancers arising in mucosal epithelial tissues, such as the colon. However, little is known about microbe-reactive T cells within human breast ducts and whether these impact breast carcinogenesis. Methods Epithelia...

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Bibliographic Details
Main Authors: Nicholas A. Zumwalde, Jill D. Haag, Michael N. Gould, Jenny E. Gumperz
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Breast Cancer Research
Subjects:
Mucosal associated invariant T (MAIT) cells
Breast duct
Breast carcinoma
Microbe-reactive human T cells
NKG2D ligands
Th17 response
Online Access:http://link.springer.com/article/10.1186/s13058-018-1036-5

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http://link.springer.com/article/10.1186/s13058-018-1036-5

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