Different toll-like receptor stimuli have a profound impact on cytokines required to break tolerance and induce autoimmunity.
Although toll-like receptor (TLR) signals are critical for promoting antigen presenting cell maturation, it remains unclear how stimulation via different TLRs influence dendritic cell (DC) function and the subsequent adaptive response in vivo. Furthermore, the relationship between TLR-induced cytoki...
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2011-01-01
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doaj-4bd2c904b5c8404c9fb61b7a7edb4a4e2020-11-25T01:51:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0169e2394010.1371/journal.pone.0023940Different toll-like receptor stimuli have a profound impact on cytokines required to break tolerance and induce autoimmunity.Albert C C LinDilan DissanayakeSalim DhanjiAlisha R ElfordPamela S OhashiAlthough toll-like receptor (TLR) signals are critical for promoting antigen presenting cell maturation, it remains unclear how stimulation via different TLRs influence dendritic cell (DC) function and the subsequent adaptive response in vivo. Furthermore, the relationship between TLR-induced cytokine production by DCs and the consequences on the induction of a functional immune response is not clear. We have established a murine model to examine whether TLR3 or TLR4 mediated DC maturation has an impact on the cytokines required to break tolerance and induce T-cell-mediated autoimmunity. Our study demonstrates that IL-12 is not absolutely required for the induction of a CD8 T-cell-mediated tissue specific immune response, but rather the requirement for IL-12 is determined by the stimuli used to mature the DCs. Furthermore, we found that IFNα is a critical pathogenic component of the cytokine milieu that circumvents the requirement for IL-12 in the induction of autoimmunity. These studies illustrate how different TLR stimuli have an impact on DC function and the induction of immunity.http://europepmc.org/articles/PMC3171407?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Albert C C Lin Dilan Dissanayake Salim Dhanji Alisha R Elford Pamela S Ohashi |
spellingShingle |
Albert C C Lin Dilan Dissanayake Salim Dhanji Alisha R Elford Pamela S Ohashi Different toll-like receptor stimuli have a profound impact on cytokines required to break tolerance and induce autoimmunity. PLoS ONE |
author_facet |
Albert C C Lin Dilan Dissanayake Salim Dhanji Alisha R Elford Pamela S Ohashi |
author_sort |
Albert C C Lin |
title |
Different toll-like receptor stimuli have a profound impact on cytokines required to break tolerance and induce autoimmunity. |
title_short |
Different toll-like receptor stimuli have a profound impact on cytokines required to break tolerance and induce autoimmunity. |
title_full |
Different toll-like receptor stimuli have a profound impact on cytokines required to break tolerance and induce autoimmunity. |
title_fullStr |
Different toll-like receptor stimuli have a profound impact on cytokines required to break tolerance and induce autoimmunity. |
title_full_unstemmed |
Different toll-like receptor stimuli have a profound impact on cytokines required to break tolerance and induce autoimmunity. |
title_sort |
different toll-like receptor stimuli have a profound impact on cytokines required to break tolerance and induce autoimmunity. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2011-01-01 |
description |
Although toll-like receptor (TLR) signals are critical for promoting antigen presenting cell maturation, it remains unclear how stimulation via different TLRs influence dendritic cell (DC) function and the subsequent adaptive response in vivo. Furthermore, the relationship between TLR-induced cytokine production by DCs and the consequences on the induction of a functional immune response is not clear. We have established a murine model to examine whether TLR3 or TLR4 mediated DC maturation has an impact on the cytokines required to break tolerance and induce T-cell-mediated autoimmunity. Our study demonstrates that IL-12 is not absolutely required for the induction of a CD8 T-cell-mediated tissue specific immune response, but rather the requirement for IL-12 is determined by the stimuli used to mature the DCs. Furthermore, we found that IFNα is a critical pathogenic component of the cytokine milieu that circumvents the requirement for IL-12 in the induction of autoimmunity. These studies illustrate how different TLR stimuli have an impact on DC function and the induction of immunity. |
url |
http://europepmc.org/articles/PMC3171407?pdf=render |
work_keys_str_mv |
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