High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma

High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma

Abstract Background Long-chain acyl-CoA synthetase-4 (ACSL4) is involved in fatty acid metabolism, and aberrant ACSL4 expression could be either tumorigenic or tumor-suppressive in different tumor types. However, the function and clinical significance of ACSL4 in lung adenocarcinoma remain elusive....

Full description

Bibliographic Details
Main Authors: Yixiang Zhang, Songyu Li, Fengzhou Li, Changsheng Lv, Qing-kai Yang
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Biology Direct
Subjects:
Long-chain acyl-CoA synthetase-4
Ferroptosis
Lung adenocarcinoma
High-fat diet
Online Access:https://doi.org/10.1186/s13062-021-00294-7

Internet

https://doi.org/10.1186/s13062-021-00294-7

Similar Items