Immune Checkpoints in Leprosy: Immunotherapy As a Feasible Approach to Control Disease Progression

Immune Checkpoints in Leprosy: Immunotherapy As a Feasible Approach to Control Disease Progression

Leprosy remains a health problem in several countries. Current management of patients with leprosy is complex and requires multidrug therapy. Nonetheless, antibiotic treatment is insufficient to prevent nerve disabilities and control Mycobacterium leprae. Successful infectious disease treatment dema...

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Bibliographic Details
Main Authors: Hayana Ramos Lima, Thaís Helena Gasparoto, Tatiana Salles de Souza Malaspina, Vinícius Rizzo Marques, Marina Jurado Vicente, Elaine Camarinha Marcos, Fabiana Corvolo Souza, Maria Renata Sales Nogueira, Jaison Antônio Barreto, Gustavo Pompermaier Garlet, João Santana da Silva, Vânia Nieto Brito-de-Souza, Ana Paula Campanelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
immunotherapy
leprosy
T-regulatory cells
immune checkpoint blockade
PD-1:PD-L1
cytotoxic T-lymphocyte-associated protein 4
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01724/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01724/full

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