Phenylmethimazole Suppresses dsRNA-Induced Cytotoxicity and Inflammatory Cytokines in Murine Pancreatic Beta Cells and Blocks Viral Acceleration of Type 1 Diabetes in NOD Mice

Phenylmethimazole Suppresses dsRNA-Induced Cytotoxicity and Inflammatory Cytokines in Murine Pancreatic Beta Cells and Blocks Viral Acceleration of Type 1 Diabetes in NOD Mice

Accumulating evidence supports a role for viruses in the pathogenesis of type 1 diabetes mellitus (T1DM). Activation of dsRNA-sensing pathways by viral dsRNA induces the production of inflammatory cytokines and chemokines that trigger beta cell apoptosis, insulitis, and autoimmune-mediated beta cell...

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Bibliographic Details
Main Authors: Fabian Benencia, Ramiro Malgor, Frank L. Schwartz, Maria C. Courreges, Jean R. Thuma, Calvin B. L. James, Kelly D. McCall, Martin J. Schmerr
Format: Article
Language:English
Published: MDPI AG 2013-03-01
Series:Molecules
Subjects:
type 1diabetes
dsRNA
beta cell death
phenylmethimazole (C10)
Online Access:http://www.mdpi.com/1420-3049/18/4/3841

Internet

http://www.mdpi.com/1420-3049/18/4/3841

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