Design of Peptidomimetic Functionalized Cholesterol Based Lipid Nanoparticles for Efficient Delivery of Therapeutic Nucleic Acids

Design of Peptidomimetic Functionalized Cholesterol Based Lipid Nanoparticles for Efficient Delivery of Therapeutic Nucleic Acids

Lipid nanoparticles (LNP) are the most potent carriers for the delivery of nucleic acid-based therapeutics. The first FDA approved a short interfering RNA (siRNA) drug that uses a cationic LNP system for the delivery of siRNA against human transthyretin (hTTR). However, preparation of such LNP invol...

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Bibliographic Details
Main Authors: Ehexige Ehexige, Tsogzolmaa Ganbold, Xiang Yu, Shuqin Han, Huricha Baigude
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Molecules
Subjects:
siRNA
lipid nanoparticle
peptidomimetic
cholesterol
Plk1
Online Access:https://www.mdpi.com/1420-3049/24/18/3413

Internet

https://www.mdpi.com/1420-3049/24/18/3413

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