ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal

ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal

Nanog regulates human and mouse embryonic stem (ES) cell self-renewal activity. Activation of ERKs signaling negatively regulates ES cell self-renewal and induces differentiation, but the mechanisms are not understood. We found that ERK1 binds and phosphorylates Nanog. Activation of MEK/ERKs signali...

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Bibliographic Details
Main Authors: Sung-Hyun Kim, Myoung Ok Kim, Yong-Yeon Cho, Ke Yao, Dong Joon Kim, Chul-Ho Jeong, Dong Hoon Yu, Ki Beom Bae, Eun Jin Cho, Sung Keun Jung, Mee Hyun Lee, Hanyong Chen, Jae Young Kim, Ann M. Bode, Zigang Dong
Format: Article
Language:English
Published: Elsevier 2014-07-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506114000373

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http://www.sciencedirect.com/science/article/pii/S1873506114000373

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