Dammarane triterpenes targeting α-synuclein: biological activity and evaluation of binding sites by molecular docking

Dammarane triterpenes targeting α-synuclein: biological activity and evaluation of binding sites by molecular docking

Parkinson's disease (PD) is a neurodegenerative disorder that affects adult people whose treatment is palliative. Thus, we decided to test three dammarane triterpenes 1, 1a, 1b, and we determined that 1 and 1a inhibit β-aggregation through thioflavine T rather than 1b. Since compound 1 was most...

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Bibliographic Details
Main Authors: Alberto Cornejo, Julio Caballero, Mario Simirgiotis, Vanessa Torres, Luisa Sánchez, Nicolás Díaz, Marcela Guimaraes, Marcos Hernández, Carlos Areche, Sergio Alfaro, Leonardo Caballero, Francisco Melo
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
parkinson’s disease
oligomers
drug target
natural compounds modifiers
Online Access:http://dx.doi.org/10.1080/14756366.2020.1851216

Internet

http://dx.doi.org/10.1080/14756366.2020.1851216

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