Antibody-Dependent Cellular Cytotoxicity (ADCC)-Mediating Antibodies Constrain Neutralizing Antibody Escape Pathway

Antibody-Dependent Cellular Cytotoxicity (ADCC)-Mediating Antibodies Constrain Neutralizing Antibody Escape Pathway

Both neutralization and antibody-dependent cellular cytotoxicity (ADCC) may be required for effective protection against HIV-1 infection. While there is extensive information on the targets of early neutralizing antibody (nAb) responses, much less is known about the targets of ADCC responses, which...

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Bibliographic Details
Main Authors: Dieter Mielke, Gama Bandawe, Justin Pollara, Melissa-Rose Abrahams, Tinashe Nyanhete, Penny L. Moore, Ruwayhida Thebus, Nicole L. Yates, John C. Kappes, Christina Ochsenbauer, Nigel Garrett, Salim Abdool Karim, Georgia D. Tomaras, David Montefiori, Lynn Morris, Guido Ferrari, Carolyn Williamson
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
ADCC
CD4-induced
neutralizing antibody
selection
escape
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02875/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02875/full

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