Global and local architecture of the mammalian microRNA-transcription factor regulatory network.

microRNAs (miRs) are small RNAs that regulate gene expression at the posttranscriptional level. It is anticipated that, in combination with transcription factors (TFs), they span a regulatory network that controls thousands of mammalian genes. Here we set out to uncover local and global architectura...

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Bibliographic Details
Main Authors: Reut Shalgi, Daniel Lieber, Moshe Oren, Yitzhak Pilpel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-07-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC1914371?pdf=render