PKCɛ switches Aurora B specificity to exit the abscission checkpoint

The Aurora B abscission checkpoint is activated when DNA is retained in the cleavage furrow on completion of anaphase. Here the authors show that PKCɛ directly phosphorylates Aurora B triggering a switch in Aurora B substrate specificity to elicit Borealin phosphorylation and abscission checkpoint e...

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Bibliographic Details
Main Authors: Tanya Pike, Nicola Brownlow, Svend Kjaer, Jeremy Carlton, Peter J. Parker
Format: Article
Language:English
Published: Nature Publishing Group 2016-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13853