Simple biophysics underpins collective conformations of the intrinsically disordered proteins of the Nuclear Pore Complex

Simple biophysics underpins collective conformations of the intrinsically disordered proteins of the Nuclear Pore Complex

Nuclear Pore Complexes (NPCs) are key cellular transporter that control nucleocytoplasmic transport in eukaryotic cells, but its transport mechanism is still not understood. The centerpiece of NPC transport is the assembly of intrinsically disordered polypeptides, known as FG nucleoporins, lining it...

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Bibliographic Details
Main Authors: Andrei Vovk, Chad Gu, Michael G Opferman, Larisa E Kapinos, Roderick YH Lim, Rob D Coalson, David Jasnow, Anton Zilman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-05-01
Series:eLife
Subjects:
nulcear pore complex
biophysics
intrinsically disordered proteins
polymers
phase separation
theory
Online Access:https://elifesciences.org/articles/10785

Internet

https://elifesciences.org/articles/10785

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