Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia

Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia

Abstract Background Artemisinin resistance is associated with delayed parasite clearance half-life in vivo and correlates with ring-stage survival under dihydroartemisinin in vitro. Both phenotypes are associated with mutations in the PF3D7_1343700 pfkelch13 gene. Recent spread of artemisinin resist...

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Bibliographic Details
Main Authors: Angana Mukherjee, Selina Bopp, Pamela Magistrado, Wesley Wong, Rachel Daniels, Allison Demas, Stephen Schaffner, Chanaki Amaratunga, Pharath Lim, Mehul Dhorda, Olivo Miotto, Charles Woodrow, Elizabeth A. Ashley, Arjen M. Dondorp, Nicholas J. White, Dyann Wirth, Rick Fairhurst, Sarah K. Volkman
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Malaria Journal
Subjects:
Plasmodium falciparum
Artemisinin resistance
pfkelch13
Piperaquine resistance
Online Access:http://link.springer.com/article/10.1186/s12936-017-1845-5

Internet

http://link.springer.com/article/10.1186/s12936-017-1845-5

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