HIV restriction factor APOBEC3G binds in multiple steps and conformations to search and deaminate single-stranded DNA

HIV restriction factor APOBEC3G binds in multiple steps and conformations to search and deaminate single-stranded DNA

APOBEC3G (A3G), an enzyme expressed in primates with the potential to inhibit human immunodeficiency virus type 1 (HIV-1) infectivity, is a single-stranded DNA (ssDNA) deoxycytidine deaminase with two domains, a catalytically active, weakly ssDNA binding C-terminal domain (CTD) and a catalytically in...

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Bibliographic Details
Main Authors: Michael Morse, M Nabuan Naufer, Yuqing Feng, Linda Chelico, Ioulia Rouzina, Mark C Williams
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
force spectroscopy
protein-DNA binding
oligomerization
facilitated diffusion
HIV-1 restriction
Online Access:https://elifesciences.org/articles/52649

Internet

https://elifesciences.org/articles/52649

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