Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin

Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin

Somatostatin is a regulatory peptide and acts as an endogenous inhibitory regulator of the secretory and proliferative responses of target cells. Somatostatin’s actions are mediated by a family of seven transmembrane domain G protein-coupled receptors that comprise five distinct subtypes (SSTR1-5)....

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Bibliographic Details
Main Authors: Charles eBrunicardi, Guisheng eZhou, Jim eSinnett-Smith, Shi-He eLiu, Juehua eYu, James eWu, Robbi eSanchez, Stephen J Pandol, Ravinder eAbrol, John eNemunaitis, Enrique eRozengurt
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Physiology
Subjects:
Somatostatin
Single nucleotide polymorphisms
G protein-coupled receptors
pancreatic and duodenal homeobox-1
somatostatin receptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00226/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00226/full

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