Candida albicans Hyphal Expansion Causes Phagosomal Membrane Damage and Luminal Alkalinization

Candida albicans Hyphal Expansion Causes Phagosomal Membrane Damage and Luminal Alkalinization

C. albicans is the most common cause of nosocomial fungal infection, and over 3 million people acquire life-threatening invasive fungal infections every year. Even if antifungal drugs exist, almost half of these patients will die. Despite this, fungi remain underestimated as pathogens. Our study use...

Full description

Bibliographic Details
Main Authors: Johannes Westman, Gary Moran, Selene Mogavero, Bernhard Hube, Sergio Grinstein
Format: Article
Language:English
Published: American Society for Microbiology 2018-09-01
Series:mBio
Subjects:
Candida albicans
candidalysin
ECE1
alkalinization
ammonia
dual-wavelength radiometric imaging
hypha
macrophages
pH
phagocytosis
phagosome
yeast-to-hypha transition
Online Access:https://doi.org/10.1128/mBio.01226-18

Internet

https://doi.org/10.1128/mBio.01226-18

Similar Items