How to Make an Immune System and a Foreign Host Quickly Cohabit in Peace? The Challenge of Acute Graft-Versus-Host Disease Prevention After Allogeneic Hematopoietic Cell Transplantation

How to Make an Immune System and a Foreign Host Quickly Cohabit in Peace? The Challenge of Acute Graft-Versus-Host Disease Prevention After Allogeneic Hematopoietic Cell Transplantation

Allogeneic hematopoietic cell transplantation (alloHCT) has been used as cellular immunotherapy against hematological cancers for more than six decades. Its therapeutic efficacy relies on the cytoreductive effects of the conditioning regimen but also on potent graft-versus-tumor (GVT) reactions medi...

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Bibliographic Details
Main Authors: Benoît Vandenhove, Lorenzo Canti, Hélène Schoemans, Yves Beguin, Frédéric Baron, Carlos Graux, Tessa Kerre, Sophie Servais
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
allogeneic stem cell transplantation
acute graft-versus-host disease
T cells
alloreactivity
immune tolerance
tissue tolerance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.583564/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.583564/full

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