HA stabilization promotes replication and transmission of swine H1N1 gamma influenza viruses in ferrets

HA stabilization promotes replication and transmission of swine H1N1 gamma influenza viruses in ferrets

Pandemic influenza A viruses can emerge from swine, an intermediate host that supports adaptation of human-preferred receptor-binding specificity by the hemagglutinin (HA) surface antigen. Other HA traits necessary for pandemic potential are poorly understood. For swine influenza viruses isolated in...

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Bibliographic Details
Main Authors: Meng Hu, Guohua Yang, Jennifer DeBeauchamp, Jeri Carol Crumpton, Hyunsuh Kim, Lei Li, Xiu-Feng Wan, Lisa Kercher, Andrew S Bowman, Robert G Webster, Richard J Webby, Charles J Russell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Series:eLife
Subjects:
influenza A virus
swine viruses
viral fusion protein
virus transmissibility
virus adaptation
Online Access:https://elifesciences.org/articles/56236

Internet

https://elifesciences.org/articles/56236

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