Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease

Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease

Background: Identification of mechanisms promoting neutrophil trafficking to the lungs of patients with cystic fibrosis (CF) is a challenge for next generation therapeutics. Cholesterol, a structural component of neutrophil plasma membranes influences cell adhesion, a key step in transmigration. The...

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Bibliographic Details
Main Authors: Michelle M. White, Patrick Geraghty, Elaine Hayes, Stephen Cox, William Leitch, Bader Alfawaz, Gillian M. Lavelle, Oliver J. McElvaney, Ryan Flannery, Joanne Keenan, Paula Meleady, Michael Henry, Martin Clynes, Cedric Gunaratnam, Noel G. McElvaney, Emer P. Reeves
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:EBioMedicine
Subjects:
Cystic fibrosis
Neutrophils
Cholesterol
Lung transplant therapy
Ivacaftor therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417303304

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http://www.sciencedirect.com/science/article/pii/S2352396417303304

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