ROS-Mediated Cytotoxic Effect of Copper(II) Hydrazone Complexes against Human Glioma Cells

ROS-Mediated Cytotoxic Effect of Copper(II) Hydrazone Complexes against Human Glioma Cells

2-Acetylpyridine acetylhydrazone (H2AcMe), 2-benzoylpyridine acetylhydrazone (H2BzMe) and complexes [Cu(H2AcMe)Cl2] (1) and [Cu(H2BzMe)Cl2] (2) were assayed for their cytotoxicity against wild type p53 U87 and mutant p53 T98 glioma cells, and against MRC-5 fibroblast cells. Compounds 1 and 2 proved...

Full description

Bibliographic Details
Main Authors: Angel A. Recio Despaigne, Jeferson G. Da Silva, Pryscila R. da Costa, Raquel G. dos Santos, Heloisa Beraldo
Format: Article
Language:English
Published: MDPI AG 2014-10-01
Series:Molecules
Subjects:
pyridine-derived hydrazones
copper(II) complexes
cytotoxicity
glioma cells
ROS generation
Online Access:http://www.mdpi.com/1420-3049/19/11/17202

Internet

http://www.mdpi.com/1420-3049/19/11/17202

Similar Items