Interactions between copy number and expression level of genes involved in fluconazole resistance in Candida glabrata

Interactions between copy number and expression level of genes involved in fluconazole resistance in Candida glabrata

Objectives. This study aimed to elucidate the relative involvement of drug resistance gene copy number and overexpression in fluconazole resistance in clinical C. glabrata isolates using a population-based approach. Methods. Fluconazole resistance levels were quantified using the minimal inhibitory...

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Bibliographic Details
Main Authors: Salma eAbbes, Hayet eSellami, Annie eMichel-Nguyen, Ali eAyadi, Stéphane eRanque
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Candida glabrata
Fluconazole
Gene Expression
human infectious agents
resistance mechanisms
gene copy number; quantitative real-time PCR
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00074/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00074/full

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