Chitosan Coated Microparticles Enhance Simvastatin Colon Targeting and Pro-Apoptotic Activity

Chitosan Coated Microparticles Enhance Simvastatin Colon Targeting and Pro-Apoptotic Activity

This work aimed at improving the targeting and cytotoxicity of simvastatin (SMV) against colon cancer cells. SMV was encapsulated in chitosan polymers, followed by eudragit S100 microparticles. The release of SMV double coated microparticles was dependent on time and pH. At pH 7.4 maximum release wa...

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Bibliographic Details
Main Authors: Nabil A. Alhakamy, Usama A. Fahmy, Osama A. A. Ahmed, Giuseppe Caruso, Filippo Caraci, Hani Z. Asfour, Muhammed A. Bakhrebah, Mohammad N. Alomary, Wesam H. Abdulaal, Solomon Z. Okbazghi, Ashraf B. Abdel-Naim, Basma G. Eid, Hibah M. Aldawsari, Mallesh Kurakula, Amir I. Mohamed
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Marine Drugs
Subjects:
chitosan
simvastatin
drug release
microparticles
mucoadhesion
Online Access:https://www.mdpi.com/1660-3397/18/4/226

Internet

https://www.mdpi.com/1660-3397/18/4/226

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