A Phase Ib Clinical Trial of Metformin and Chloroquine in Patients with <i>IDH1</i>-Mutated Solid Tumors

A Phase Ib Clinical Trial of Metformin and Chloroquine in Patients with <i>IDH1</i>-Mutated Solid Tumors

Background: Mutations in isocitrate dehydrogenase 1 (<i>IDH1</i>) occur in 60% of chondrosarcoma, 80% of WHO grade II-IV glioma and 20% of intrahepatic cholangiocarcinoma. These solid <i>IDH1</i>-mutated tumors produce the oncometabolite <i>D</i>-2-hydroxyglutarat...

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Bibliographic Details
Main Authors: Mohammed Khurshed, Remco J. Molenaar, Myra E. van Linde, Ron A. Mathôt, Eduard A. Struys, Tom van Wezel, Cornelis J. F. van Noorden, Heinz-Josef Klümpen, Judith V. M. G. Bovée, Johanna W. Wilmink
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
metformin
chloroquine
cancer
isocitrate dehydrogenase
pharmacokinetics
glioblastoma
Online Access:https://www.mdpi.com/2072-6694/13/10/2474

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https://www.mdpi.com/2072-6694/13/10/2474

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