Enhanced Function and Overexpression of Metabotropic Glutamate Receptors 1 and 5 in the Spinal Cord of the SOD1<sup>G93A</sup> Mouse Model of Amyotrophic Lateral Sclerosis during Disease Progression

Enhanced Function and Overexpression of Metabotropic Glutamate Receptors 1 and 5 in the Spinal Cord of the SOD1<sup>G93A</sup> Mouse Model of Amyotrophic Lateral Sclerosis during Disease Progression

Glutamate (Glu)-mediated excitotoxicity is a major cause of amyotrophic lateral sclerosis (ALS) and our previous work highlighted that abnormal Glu release may represent a leading mechanism for excessive synaptic Glu. We demonstrated that group I metabotropic Glu receptors (mGluR1, mGluR5) produced...

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Bibliographic Details
Main Authors: Tiziana Bonifacino, Claudia Rebosio, Francesca Provenzano, Carola Torazza, Matilde Balbi, Marco Milanese, Luca Raiteri, Cesare Usai, Ernesto Fedele, Giambattista Bonanno
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
amyotrophic lateral sclerosis
SOD1<sup>G93A</sup> mice
spinal cord
metabotropic glutamate receptor 1 (mGluR1)
metabotropic glutamate receptor 5 (mGluR5)
glutamate release
mGluR1/mGluR5 expression
disease progression
Online Access:https://www.mdpi.com/1422-0067/20/18/4552

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https://www.mdpi.com/1422-0067/20/18/4552

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