Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast Cancer

Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast Cancer

Dependence on the glutamine pathway is increased in advanced breast cancer cell models and tumors regardless of hormone receptor status or function. While 70% of breast cancers are estrogen receptor positive (ER+) and depend on estrogen signaling for growth, advanced ER+ breast cancers grow independ...

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Bibliographic Details
Main Authors: Diane M. Demas, Susan Demo, Yassi Fallah, Robert Clarke, Kenneth P. Nephew, Sandra Althouse, George Sandusky, Wei He, Ayesha N. Shajahan-Haq
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Oncology
Subjects:
breast cancer
endocrine resistance
glutamine metabolism
mTOR
CB-839
everolimus
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00686/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00686/full

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