Identification of antithrombin-modulating genes. Role of LARGE, a gene encoding a bifunctional glycosyltransferase, in the secretion of proteins?

Identification of antithrombin-modulating genes. Role of LARGE, a gene encoding a bifunctional glycosyltransferase, in the secretion of proteins?

The haemostatic relevance of antithrombin together with the low genetic variability of SERPINC1, and the high heritability of plasma levels encourage the search for modulating genes. We used a hypothesis-free approach to identify these genes, evaluating associations between plasma antithrombin and 3...

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Bibliographic Details
Main Authors: María Eugenia de la Morena-Barrio, Alfonso Buil, Ana Isabel Antón, Irene Martínez-Martínez, Antonia Miñano, Ricardo Gutiérrez-Gallego, José Navarro-Fernández, Sonia Aguila, Juan Carlos Souto, Vicente Vicente, José Manuel Soria, Javier Corral
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3660365?pdf=render

Internet

http://europepmc.org/articles/PMC3660365?pdf=render

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