Intraperitoneal collagenase as a novel therapeutic approach in an experimental model of colorectal peritoneal carcinomatosis

Abstract The usefulness of local collagenase in therapeutic approaches to solid tumors has been tested recently. In this study, we evaluate the safety and efficacy of intraperitoneal collagenase associated or not to mitomycin for treatment of colorectal peritoneal metastases in an experimental rat m...

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Bibliographic Details
Main Authors: D. García-Olmo, P. Villarejo Campos, J. Barambio, S. Garcia Gomez-Heras, L. Vega-Clemente, S. Olmedillas-Lopez, H. Guadalajara, M. Garcia-Arranz
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79721-0