The role of high airway pressure and dynamic strain on ventilator-induced lung injury in a heterogeneous acute lung injury model

The role of high airway pressure and dynamic strain on ventilator-induced lung injury in a heterogeneous acute lung injury model

Abstract Background Acute respiratory distress syndrome causes a heterogeneous lung injury with normal and acutely injured lung tissue in the same lung. Improperly adjusted mechanical ventilation can exacerbate ARDS causing a secondary ventilator-induced lung injury (VILI). We hypothesized that a pe...

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Bibliographic Details
Main Authors: Sumeet V. Jain, Michaela Kollisch-Singule, Joshua Satalin, Quinn Searles, Luke Dombert, Osama Abdel-Razek, Natesh Yepuri, Antony Leonard, Angelika Gruessner, Penny Andrews, Fabeha Fazal, Qinghe Meng, Guirong Wang, Louis A. Gatto, Nader M. Habashi, Gary F. Nieman
Format: Article
Language:English
Published: SpringerOpen 2017-05-01
Series:Intensive Care Medicine Experimental
Subjects:
Acute lung injury
Over-distension
Stress
Strain
Heterogeneous lung
Atelectasis
Online Access:http://link.springer.com/article/10.1186/s40635-017-0138-1

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http://link.springer.com/article/10.1186/s40635-017-0138-1

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